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Chrono Virus

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In March 2020, the World Health Organization (WHO) initiated the Solidarity trial to assess the treatment effects of some promising drugs: an experimental drug called remdesivir; anti-malarial drugs chloroquine and hydroxychloroquine; two anti-HIV drugs, lopinavir/ritonavir; and interferon-beta. [485] [486] More than 300 active clinical trials are underway as of April 2020. [68]

Covid map: Coronavirus cases, deaths, vaccinations by country Covid map: Coronavirus cases, deaths, vaccinations by country

a b c d e • "COVID-19: epidemiology, virology and clinical features". GOV.UK . Retrieved 18 October 2020. a b Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF (April 2020). "The proximal origin of SARS-CoV-2". Nature Medicine. 26 (4): 450–452. doi: 10.1038/s41591-020-0820-9. PMC 7095063. PMID 32284615. Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19". World Health Organization (WHO). 15 May 2020 . Retrieved 20 May 2020.

Spotlight

It is unknown whether different persons use similar antibody genes in response to COVID‑19. [155] Host cytokine response Mild versus severe immune response during virus infection Humans appear to be capable of spreading the virus to some other animals, [459] [460] a type of disease transmission referred to as zooanthroponosis. [461] [462] Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), proper intake of fluids, rest, and nasal breathing. [265] [266] [267] [268] Good personal hygiene and a healthy diet are also recommended. [269] As of April 2020 the U.S. Centers for Disease Control and Prevention (CDC) recommended that those who suspect they are carrying the virus isolate themselves at home and wear a face mask. [270]

COVID-19 - NHS

The effect of the virus on ACE2 cell surfaces leads to leukocytic infiltration, increased blood vessel permeability, alveolar wall permeability, as well as decreased secretion of lung surfactants. These effects cause the majority of the respiratory symptoms. However, the aggravation of local inflammation causes a cytokine storm eventually leading to a systemic inflammatory response syndrome. [153] World Health Organization Best Practices for the Naming of New Human Infectious Diseases (PDF) (Report). World Health Organization (WHO). May 2015. hdl: 10665/163636. diffuse alveolar damage (DAD) with diffuse alveolar exudates. DAD is the cause of acute respiratory distress syndrome (ARDS) and severe hypoxaemia. [119]As of 1October2021 [update], Reuters reported that it had estimated the worldwide total number of deaths due to COVID‑19 to have exceeded five million. [451] Novel coronavirus named 'Covid-19': WHO". Today. Singapore. Archived from the original on 21 March 2020 . Retrieved 11 February 2020. In November 2020, the US Food and Drug Administration (FDA) issued an emergency use authorisation for the investigational monoclonal antibody therapy bamlanivimab for the treatment of mild-to-moderate COVID‑19. [501] Bamlanivimab is authorised for people with positive results of direct SARS-CoV-2 viral testing who are twelve years of age and older weighing at least 40 kilograms (88lb), and who are at high risk for progressing to severe COVID‑19 or hospitalisation. [501] This includes those who are 65 years of age or older, or who have chronic medical conditions. [501]

Covid in the UK: cases, deaths and vaccinations – the latest

Stadnytskyi, Valentyn; Bax, Christina E.; Bax, Adriaan; Anfinrud, Philip (2 June 2020). "The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission". Proceedings of the National Academy of Sciences. 117 (22): 11875–11877. Bibcode: 2020PNAS..11711875S. doi: 10.1073/pnas.2006874117. PMC 7275719. PMID 32404416.a b Gandhi RT, Lynch JB, Del Rio C (October 2020). "Mild or Moderate Covid-19". The New England Journal of Medicine. 383 (18): 1757–1766. doi: 10.1056/NEJMcp2009249. PMID 32329974. a b Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S, Ma K (February 2021). "A systematic review of asymptomatic infections with COVID-19". Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi. 54 (1): 12–16. doi: 10.1016/j.jmii.2020.05.001. PMC 7227597. PMID 32425996.

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