Powerful 50 Billion CFU Probiotics - 18 Strains, Stomach Acid Resistant, Shelf Stable | Highest Strength Bacterial Cultures – Keeps Digestive System Healthy | 60 Vegan Capsules for Men and Women
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The excess histamine is then absorbed through the lining of the intestinal tract and into the bloodstream, causing symptoms similar to an allergic reaction ( 27). The most common amines found in probiotic-rich foods include histamine, tyramine, tryptamine and phenylethylamine ( 14). Probiotics are safe for the vast majority of the population, but may not be the best fit for everyone.
Similarly, yeast-based probiotics should not be taken by those with yeast allergies. Instead, a bacteria-based probiotic should be used ( 33). When a supplement contains both probiotic microorganisms and prebiotic fibers, it is called a synbiotic ( 39) . While studies suggest that most people with lactose intolerance can tolerate up to 400 mg of lactose in medications or supplements, there have been case reports of adverse effects from probiotics ( 35, 36, 37).Those at greatest risk for infection from probiotics include people with suppressed immune systems, prolonged hospitalizations, venous catheters or those who have undergone recent surgeries ( 45, 46, 47). This process creates redness and swelling in the affected area, and can also trigger allergy symptoms such as itching, watery eyes, runny nose or trouble breathing.
When infections do occur, they typically respond well to traditional antibiotics or antifungals. However, in rare cases, deaths have occurred ( 48, 50). When histamine levels rise, blood vessels dilate to bring more blood to the affected area. The vessels also become more permeable so that immune cells can easily get into the relevant tissue to combat any pathogens ( 22).It is estimated that only about one in one million people who take probiotics containing Lactobacilli bacteria will develop an infection. The risk is even smaller for yeast-based probiotics, with only about one in 5.6 million users getting infected ( 48, 49).
Since a small number of people with lactose intolerance may experience unpleasant gas and bloating when consuming lactose-containing probiotics, they may want to choose lactose-free products. More research is needed to determine whether or not amines can be direct triggers of headaches or migraines in some people.Biogenic amines are substances that form when protein-containing foods age or are fermented by bacteria ( 13). One study found that low-histamine diets reduced headaches in 75% of participants. However, a review of 10 controlled studies found no significant effect of dietary amines on headaches ( 17, 18). However, some people with histamine intolerance have trouble properly breaking down the histamine in their bodies, seeing as they do not produce enough DAO ( 24, 25, 26).